Knowing when to make use of a large multi picture frames is something, like many other topics in photography, that comes partly with experience. Some photographs seem almost destined to stand alone, and forcing such a picture into a frame with others will never be productive. On the other hand, there are also effects that can really only be achieved through the display of two or more photographs in intimate proximity with one another. When such opportunities arise, putting just as much effort into the selection of multi picture frames as with traditional ones will always be worthwhile.
Many of the skills that help with conventional frame selection will also transfer readily to the realm of multi aperture frames. Most photographers quickly become familiar with how different mounting approaches can support or enhance particular kinds of pictures, for instance, and this knowledge will generally hold with regard to frames that hold more than one photograph. At the same time, some adjustments will inevitably need to be made to account for the fact that the eyes of viewers will no longer be drawn to a single image but across and between a number of them.
When it comes to other details, things often become quite a bit simpler. The same style of frame border that might work well for a single picture in a certain room, for instance, will often serve a collection of them suitably, too. One issue that sometimes crops up is that frames designed to show off several pictures will often be larger than the more focused alternatives, even when each individual photograph is small. Because of this, a frame of this kind will often have an even more dominant presence when actually placed on a wall, and this will need to be accounted for, as well.